еКорпус – библиографски запис
Biochemical liver function test parameter levels in relation to treatment response in liver metastatic colorectal patients treated with FOLFOX4 with or without bevacizumab
НИВО БИОХЕМИЈСКИХ ПАРАМЕТАРА ФУНКЦИОНАЛНОГ СТАТУСА ЈЕТРЕ У ОДНОСУ НА КЛИНИЧКИ ОДГОВОР КОД БОЛЕСНИКА СА МЕТАСТАТСКИМ КОЛОРЕКТАЛНИМ КАРЦИНОМОМ КОЈИ СУ ЛЕЧЕНИ FOLFOX4 ПРОТОКОЛОМ СА БЕВАЦИЗУМАБОМ ИЛИ БЕЗ ЊЕГА
- Часопис
- Serbian Archives of Medicine
- Објављено
- Srp Arh Celok Lek. 2016;144(11–12):615–620.
- Врста рада
- ORIGINAL ARTICLES
Abstract
Introduction Combined use of bevacizumab and conventional anticancer drugs leads to a significant improvement of treatment response in patients with metastatic colorectal carcinoma (CRC). Conventional treatment protocols exert undesired effects on the liver tissue. Hepatotoxic effects are manifested as a disturbance of liver function test parameters. The relation between clinical outcome and disorder of biochemical parameters has not been completely evaluated.
Objective The objective of our study was to examine whether clinical outcome in patients with liver metastatic CRC correlates with the level of liver function test parameters.
Methods The study included 96 patients with untreated liver metastatic CRC who received FOLFOX4 protocol with or without bevacizumab. Biochemical liver parameters were performed before and after the treatment completion. Treatment response was evaluated as disease regression, stable disease, and disease progression. The patients were divided into three groups according to the accomplished treatment response.
Results In the group of patients with disease regression the post-treatment levels of aspartate aminotransferase, alanine aminotransferase, and bilirubin were statistically significantly increased. In contrast to this, gamma-glutamyltransferase and protein post-treatment values were significantly lower in relation to initial values. In patients with stable disease, difference was found only in the level of proteins being lower after the treatment. In patients with disease progression, values of aspartate aminotransferase and bilirubin were significantly increased after completed treatment.
Conclusion Treatment responses are not completely associated with the level of liver function test parameters. The only parameter which correlated with treatment response is gamma-glutamyltransferase. Its decrease is accompanied with disease regression.
Keywords: bevacizumab; colorectal liver metastases; hepatotoxicity; liver function test parameters; treatment response