Two cases of uneventful pregnancies following the treatment of choriocarcinoma

Abstract

Introduction Gestational trophoblastic disease represents a distinguished group of disorders that are derived from placental trophoblastic tissue aroused from abnormal fertilization. Choriocarcinoma is a malignant human chorionic gonadotropin-producing epithelial tumor arising from villous trophoblast. The choice of the chemotherapy regime is based on the International Federation of Gynecology and Obstetrics stage and World Health Organization score of the disease. The objective of this article is to show that successful pregnancy is possible even after treatment of high-risk gestational trophoblastic neoplasia.

Outlines of cases We present two successfully treated patients who achieved pregnancy and delivered healthy babies in term.

Conclusion Gestational trophoblastic neoplasia has become the most curable malignant disease since the introduction of chemotherapy, which is effective and well-tolerated, and allows fertility preservation in high-proportion of women.

Keywords: gestational trophoblastic neoplasia; choriocarcinoma; pregnancy; fertility