Relationship between serum AGE precursor levels, oxidative stress, and quality of life in patients receiving hemodialysis

Abstract

Introduction/Objective The aim of this study was to determine the relationship between serum advanced glycation end product (AGE) precursors, oxidative stress levels, and quality of life in hemodialysis patients.

Methods A descriptive form and the Kidney Disease Quality of Life Form (KDQOL-36) were used in the study. Serum levels of AGE precursors [methylglyoxal (MGO) and glyoxal (GO)] and oxidative stress [malondialdehyde (MDA)] were determined in blood samples taken from the patients.

Results The KDQOL-36 subscale scores were 71.65 ± 17.76 for the symptoms/problems list, 66.35 ± 19.06 for the effect of kidney disease, 40.6 ± 24.01 for the kidney disease burden, 41.6 ± 9.83 SF-12 for physical health, and 37.83 ± 9.69 for SF-12 mental health. The serum levels were 3.96 ± 1.01 μmol/L for MDA, 1029.87 ± 314.43 ng/mL for GO, and 115.2 ± 75.54 ng/mL for MGO. A positive and significant correlation was detected between serum MGO and GO (r = .285, p < 0.01) and MDA (r = 0.284, p < 0.01). A positive correlation was noted between serum MDA and GO (r = 1,000, p < 0.05) and a negative correlation with kidney disease burden (r = -0.205, p < 0.05). A negative and significant correlation was detected between GO and kidney disease burden (r = -0.204, p < 0.05).

Conclusion Serum MGO, GO, and MDA levels were high in patients undergoing hemodialysis. High serum MDA levels are associated with high serum GO and MGO levels. High serum levels of MDA and GO had a negative impact on the quality of life of hemodialysis patients.

Keywords: hemodialysis; oxidative stress; serum advanced glycation end product precursor; quality of life