REZISTENCIJA GLJIVA NA ANTIMIKOTIKE: MEHANIZMI NASTANKA, UČESTALOST, PREVENCIJA I KONTROLA REZISTENCIJE

Abstract

Fungi are important causes of human infections, especially systemic mycoses. Pathogenic fungi have many complex mechanisms of resistance to antifungal drugs. In this article, information about the cellular, genetic and clinical factors contributing to antifungal-drug resistance, and their diagnostic and epidemiologic characteristics are reviewed. Understanding the mechanisms of resistance should assist in developing better detection and preventive strategies. The emergence of acquired antifungal resistance, especially in immunocompromised hosts, has necessitated routine antifungal susceptibility testing. Initial antifungal screening of clinical isolates by the disk-diffusion method would be followed by confirmation of resistant strains by the broth dilution method. Also, strategies to avoid and suppress the antifungal resistance are discussed. There are several strategies to overcome antifungal resistance, including increased antifungal-dose intensity, immunomodulation, combined antifungal therapy and new antifungals.

Keywords: pathogenic fungi; Candida spp.; antifungal drugs; resistance; in vitro studies