еКорпус – библиографски запис
FAVOURABLE PROGNOSTIC FACTORS IN THERAPY RELATED ACUTE MYELOID LEUKAEMIA
ПОВОЉНИ ПРОГНОСТИЧКИ ФАКТОРИ КОД БОЛЕСНИКА С АКУТНОМ МИЈЕЛОИДНОМ ЛЕУКЕМИЈОМ ИЗАЗВАНОМ ПРЕТХОДНИМ ЛЕЧЕЊЕМ
- Часопис
- Serbian Archives of Medicine
- Објављено
- Srp Arh Celok Lek. 2011;139(5–6):347–352.
- Врста рада
- ORIGINAL ARTICLES
Abstract
Introduction Therapy related acute myeloid leukaemia (t-AML) is a distinct clinical entity recognized by the World Health Organization classification occurring after chemotherapy and/or radiation treatment administered for a previous disease. T-AML is characterised by pancytopenia, three-lineage myelodysplasia, high frequency of unfavourable cytogenetics and short survival.
Objective The aim of this study was to analyse clinical, cytogenetic, and cytological characteristics of t-AML and their impact on survival.
Methods Seventeen patients with t-AML (8 male and 9 female; median age 59 years) were identified among 730 consecutive patients with acute myeloid leukaemia. The degree of three-lineage dysplasia as well as haematological, cytological and cytogenetic analyses, were assessed by standard methods.
Results The patients survived a median of 62.5 days with the 10% probability of survival during two years. Prognostically favourable factors were a higher percentage of dysplastic granulocytic cells, age less than 60 years, and presence of prognostically favourable karyotype inv(16), t(15;17), t(8;21).
Conclusion The stated prognostic factors that include age, cytogenetics findings and granulocytic dysplasia analysis could contribute to adequate risk stratification of t-AML, though fuller results would require additional analyses.
Keywords: therapy related acute myeloid leukaemia; cytology; myelodysplasia; survival