КВАЛИТЕТ ЛЕЧЕњА ОСОБА ОБОЛЕЛИх ОД ГИхТА У ОДНОСУ НА ПРЕПОРУКЕ EULAR

Abstract

Introduction There are 12 recommendations for gout treatment, based on evidence and opinion of experts.

Objective To assess the quality of therapy in patients with gout analyzing adherence to four selected recommendations.

Methods Retrospective cross sectional study of 111 patients with gouty flare was conducted. Adherence to selected recommendation was defined as odds ratio between the number of patients whose therapy adhered to treatment recommendation and the number of patients eligible for the relevant recommendation. These recommendations refer to indications for allopurinol treatment (R1), prophylaxis of induced gouty flares in the first month of allopurinol treatment (R2), treatment goals (R3), and treatment monitoring regime (R4).

Results Out of 111 patients with gout, 25 with tophi, 87 with frequent gouty flares and 46 with CUA or X-ray erosions were indicated for allopurinol treatment. The adherence to R1 was 76% for tophi patients, 54% for patients with frequent gouty flares, and 63% for patients with CUA. None of the patients starting allopurinol was either recruited for gouty prophylaxis or monitored properly; adherence to R2 as well as to R4 was 0%. Target serum uric acid (SUc) rating below 360 µmol/L was achieved in 13/50 patients treated with allopurinol, while the adherence to R3 was 26%. Therapeutic monitoring in accordance with P4 was not done in any of the patients on allopurinol. There were no differences in mean levels of the SUc between allopurinol users and non-users: 471.3±164.4 vs. 460.0±103.5 µmol/L (p=0.067). Therefore, almost every second patient with gouty flares was on allopurinol therapy (50/111).

Conclusion The degree of deviation in relation to the key principles of correct treatment in patients with gout ranged from a relatively high (24%) to that of absolute digression (100%).

Keywords: gout; treatment recommendations; quality of therapy; allopurinol