еКорпус – библиографски запис
Relationship between optic nerve head topography and nerve fiber layer thickness with central corneal thickness in patients with primary open-angle glaucoma
ПОВЕЗАНОСТ ТОПОГРАФСКИХ ПАРАМЕТАРА ГЛАВЕ ОПТИЧКОГ НЕРВА И ДЕБЉИНЕ СЛОЈА НЕРВНИХ ВЛАКАНА РЕТИНЕ СА ЦЕНТРАЛНОМ ДЕБЉИНОМ РОЖЊАЧЕ КОД БОЛЕСНИКА СА ПРИМАРНИМ ГЛАУКОМОМ ОТВОРЕНОГ УГЛА
- Часопис
- Serbian Archives of Medicine
- Објављено
- Srp Arh Celok Lek. 2020;148(11–12):723–726.
- Врста рада
- ORIGINAL ARTICLES
Abstract
Introduction/Objective In patients with primary open-angle glaucoma (POAG) we explored the relationship between the optic nerve head (ONH) topography parameters and the retinal nerve fiber layer (RNFL) thickness with the central corneal thickness (CCT).
Methods This retrospective study included 97 patients (97 eyes) with primary open-angle glaucoma. Patients were divided into a thin CCT < 540 μm (45 eyes) and a thick CCT ≥ 540 μm (52 eyes) group, using ultrasonic pachymeter. Topographic measurements of the ONH parameters and RNFL thickness was performed using optical coherence tomography (OCT). The outcomes were compared with the thin and thick CCT and correlated with the thin CCT of the subjects.
Results There were significantly lower mean intraocular pressure (p < 0.0001) and CCT (p < 0.0001) in patients with thin CCT compared to patients with thick CCT. Statistically significant differences of ONH parameters were found in thin cornea group compared to thick cornea group in: cup/disc area ratio (p < 0.03), vertical cup/disc ratio (p < 0.01) and rim volume (p < 0.01). Statistically significant differences of RNFL thickness were found in thin cornea group compared to thick cornea group in: average (p < 0.001), superior (p < 0.03), inferior (p < 0.03) and nasal (p < 0.01). Significant positive correlation was found between thin CCT and OCT parameters in: optic disc area (r = 0.429, p = 0.003), cup/disc area ratio (r = 0.287, p = 0.05), horizontal cup/disc ratio (r = 0.472, p < 0.001), vertical cup/disc ratio (r = 0.578, p < 0.001), average RNFL (r = 0.796, p < 0.001), superior RNFL (r = 0.665, p < 0.001), inferior RNFL (r = 0.650, p < 0.001), nasal RNFL (r = 0.611, p < 0.001) and temporal RNFL thickness (r = 0.601, p < 0.001).
Conclusion POAG patients with thin cornea will probably develop larger glaucoma changes than those with a thicker cornea. Ultrasonic pachymetry measurements of CCT and OCT analysis of ONH topography parameters and RNFL thickness provide significant information in early diagnosis and monitoring progression of POAG.
Keywords: intraocular pressure; ultrasonic pachymetry; optical coherence tomography