еКорпус – библиографски запис
Comparative analysis of International Prognostic Index for Chronic Lymphocytic Leukemia, progression-risk score, and MD Anderson Cancer Center 2011 score – a single center experience
УПОРЕДНА АНАЛИЗА ИНТЕРНАЦИОНАЛНОГ ПРОГНОСТИЧКОГ ИНДЕКСА ЗА ХРОНИЧНУ ЛИМФОЦИТНУ ЛЕУКЕМИЈУ, СКОРА РИЗИКА ОД ПРОГРЕСИЈЕ И СКОРА ЦЕНТРА ЗА РАК MD ANDERSON – ИСКУСТВО ЈЕДНОГ ЦЕНТРА
- Часопис
- Serbian Archives of Medicine
- Објављено
- Srp Arh Celok Lek. 2021;149(7–8):415–421.
- Врста рада
- ORIGINAL ARTICLES
Abstract
Introduction/Objective Prognostication of chronic lymphocytic leukemia (CLL) has been substantially improved in recent times. Among several prognostic models (PMs) focused on the prediction of time to first treatment (TTFT), progression-risk score (PRS), and MD Anderson Cancer Center score 2011 (MDACC 2011) are the most relevant, while CLL-International Prognostic Index (CLL-IPI), although originally developed to predict overall survival (OS), is also being used to estimate TTFT. The aim of this study was to investigate CLL-IPI, PRS, and MDACC 2011 prognostic values regarding TTFT and OS.
Methods The analyzed cohort included 57 unselected Serbian CLL patients from a single institution, with the basic characteristics reflecting more aggressive disease than in the general de novo CLL population. The eligible patients were assigned investigated PMs, and TTFT and OS analyses were performed.
Results Patients with higher risk scores according to CLL-IPI, PRS, and MDACC 2011 underwent treatment significantly earlier than patients with lower risk scores (p = 0.002, p = 0.019, and p < 0.001, respectively). In multivariate analysis, MDACC 2011 and CLL-IPI retained their significance regarding TTFT (p = 0.001 and p = 0.018, respectively), while PRS did not. CLL-IPI was the only significant predictor of OS both at the univariate (p = 0.005) and multivariate (p = 0.013) levels.
Conclusion CLL-IPI, PRS, and particularly MDACC 2011 are able to predict TTFT even in cohorts with more advanced-disease patients, while for prediction of OS, CLL-IPI is the only applicable among the three PMs. These results imply that PMs should be investigated in more diverse CLL populations, as it is in real-life setting.
Keywords: chronic lymphocytic leukemia; CLL-IPI score; progression risk score; MDACC 2011 score; overall survival; time to first treatment