ИНТРАВАСКУЛАРНИ ЛИМФОМ ЦЕНТРАЛНОГ НЕРВНОГ СИСТЕМА

Abstract

Intravascular lymphomatosis is an uncommon lymphoproliferative disorder characterised by intravascular distribution of neoplastic lymphoid cells (B- or T-lymphocites), what leads to occlusion of small vessels and causes signs and simptoms of disorder. Its initial predilection sites are the brain or the skin, and hematopoetic organs are usually spared. The signs and symptoms of the disorder are attributed to vascular occlusion. Clinical course is fatal, besides therapy. In our case disorder has started with partial epileptic seizures with secundar generalisation, and after that with motor aphasia, right hemiparesis, urinary incontinence and cognitive changes. She was hospitalized for several times, completly investigated, but with no conclusion. Seven months after appereance of simptoms, she died. And diagnosis was determined at autopsy. A myriad of neurological and sistemic manifestations are putting us in an unequal position with this fatal disease. Early diagnosis can increase survival and decrease intensity of simptoms. So every new case is important as warning that we must not forget about this disease.

Keywords: intravascular lymphomatosis, B-lymphocites, central nervious system.